This is the text extract for Asthma Dosage Chart, browse documents here.

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A

MANAGEMENT

RESOURCE

dosage

DOSE EQUIVALENCE AND BACK TITRATION FOR COMMONLY USED INHALED CORTICOSTEROIDS

• • • • Fluticasone is twice as potent as beclomethasone or budesonide When titrating dose, wait 12 weeks to judge effect

2 1

A S T H M A

Back titrate stable patients by 25% of total daily dose

2

The dose response curve for inhaled corticosteroids flattens around 500-1000µg beclomethasone/budesonide (250-500µg fluticasone) per day

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Developed and produced by PHARMAC, in association with respiratory opinion leaders.

References:

1

Best Practice Evidence-Based Guideline

The Diagnosis and Treatment of Adult Asthma, September 2002 New Zealand Guidelines Group

2

British Guideline on the Management of Asthma

Quick Reference Guide, October 2002 Scottish Intercollegiate Guidelines Network (www.sign.ac.uk) British Thoracic Society (www.brit-thoracic.org.uk)

www.pharmac.govt.nz

0800 66 00 50

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D O S E E Q U I VA L E N C E F O R C O M M O N LY U S E D I N H A L E D C O RT I C O S T E R O I D I N H A L E R S

BECLOMETHASONE

FLUTICASONE

BUDESONIDE

2000µg

250

B E C L O M E T H A S O N E E Q U I VA L E N T AT D O S E S O F 2 P U F F S T W I C E A D AY

400

very high dosage

1000µg

250 125

800µg

high dosage medium dosage

100 50

200

Most Adults with asthma can be controlled within this range, up to 500µg/day of beclomethasone (250µg fluticasone)1

400µg

100

100µg

low dosage

BECLOMETHASONE FLUTICASONE BUDESONIDE

50

25

Note: Strength categories are consistent with those outlined in the Pharmaceutical Schedule

D O S E S T R E N G T H C AT E G O R I E S F R O M P H A R M A C E U T I C A L S C H E D U L E

1600µg